Pancreatic body tail cancer leading to wandering phlebitis may be caused by blood hypercoagulable state caused by tumor, which leads to thrombus formation, or caused by tumor embolus shedding. Pancreatic body tail cancer belongs to malignant tumor of digestive system, which will cause patients’ blood to show hypercoagulable state, and more patients are accompanied by reduced physical strength, long-term bed rest, etc., which will aggravate the risk of thrombosis. After thrombosis, it will stimulate the wall of vein, leading to phlebitis, mostly manifested as wandering. Besides thrombus, the shedding of pancreatic body tail cancer cells will enter into blood circulation and gather into thrombus in blood vessels, which will lead to proliferation of venous connective tissue and inflammatory infiltration, causing wandering phlebitis. The prognosis of pancreatic body tail cancer is poor, in case of wandering phlebitis, follow the doctor’s prescription to receive standardized treatment, and recheck the coagulation function regularly.