Symptoms of monkeypox virus infection mainly include rash, muscle pain, fever, malaise, etc. According to the development of the disease, it can be divided into prodromal stage, rash stage and crust stage, and the symptoms of each stage are different. 1. Prodromal stage: patients infected with monkeypox virus have acute onset of symptoms such as fever, muscle pain, back pain, headache, fatigue, etc. Some patients may also have sore throat, which lasts for 2 days to 4 days. 2. Rash stage: the rash appears after 1 to 3 days of fever, and usually undergoes four stages, i.e., blotchy rash, papule, herpes and pustule, and spreads from the face to the limbs, and the trunk is less involved. 3. Scabbing stage: Herpes may start to scab gradually after a few days of formation, and scarring may remain after the scabs fall off. If the patient has the above symptoms and suspected to be infected by monkeypox virus, he should consult a doctor in time and complete the relevant examinations under the doctor’s guidance, such as routine blood test, serum antibody test, viral nucleic acid test, viral culture test and so on, so as to make a clear diagnosis of the disease and carry out the corresponding treatment according to the doctor’s instructions.