The recurrence of acute lymphoblastic leukemia is mainly due to the fact that the disease has not been completely cured, and leukemia cells always exist in the patient’s body. Acute lymphoblastic leukemia is a relatively serious blood disease, not only the onset of the disease is relatively rapid, but also more difficult to treat, the risk of relapse is high, even after induction chemotherapy disease remission, but most patients will still have some leukemia cells in the body. After a period of time, the remaining leukemia cells are likely to proliferate again, leading to leukemia relapse. Specific drugs include cyclophosphamide and vincristine. Once a patient has a relapse, then he or she should be treated in a timely manner, and in addition to chemotherapy, the patient may also consider allogeneic hematopoietic stem cell transplantation. However, the prognosis of patients with relapse will be poorer, and there is a possibility of multiple relapses and gradual aggravation of the disease. Therefore, patients should actively cooperate with the doctor’s treatment, go to the hospital for regular checkups, and strengthen their daily care to maintain a healthy diet and lifestyle to avoid recurrence.