Big toe gout is related to purine metabolism disorders in the body, and can be treated by colchicine and non-steroidal anti-inflammatory drugs and other drugs for pain relief. 1. Colchicine: Colchicine is the first line of gout attack treatment, the drug can play a role in controlling the local pain, swelling and inflammation of joints, effectively relieving gout attack patients with joint pain and other symptoms, but it should be noted that you need to start with a small dose of colchicine, such as diarrhea, vomiting and other adverse reactions need to be discontinued and consult a doctor immediately. 2. Non-steroidal anti-inflammatory drugs: common non-steroidal anti-inflammatory drugs, including celecoxib, etoricoxib and ibuprofen, etc., this kind of drugs can reduce the synthesis of prostaglandins and play an anti-inflammatory, analgesic effect, can alleviate the patient’s joint pain symptoms, but the use of non-steroidal anti-inflammatory drugs need to be vigilant about the risk of gastrointestinal bleeding, ulcer and so on. Drugs need to be used under the guidance of a physician, it is recommended that patients with big toe gout go to the rheumatology and immunology department of a regular hospital for further consultation, and take medication as prescribed by the doctor.