The second eradication of H. pylori why interval three months, mainly considering H. pylori drug resistance, liver and kidney function injury and other factors. 1. Helicobacter pylori drug resistance: patients eradication of Helicobacter pylori, generally choose to regularly take two antibiotics for two weeks, the amount of antibiotics at this time is larger, if not spaced out for three months to continue to take antibiotics will lead to the body of the Helicobacter pylori resistance, resulting in anti-bacterial effect is not good. 2. Liver and kidney function damage: antibiotics, acid inhibitors and other drugs to eradicate H. pylori are mainly metabolized through the liver and kidneys, eradication of H. pylori patients have eaten a lot of drugs, has been a certain impact on the liver and kidney function, if you continue to take the drug, it will aggravate the damage to the liver and kidneys, so you need to take a interval of three months, so that the effect of the drug is completely metabolized, the liver and kidneys function recovered, and then take it again. Patients must consult a physician before taking the medication, and take the medication under the guidance of the physician.