Goserelin, if resistance occurs, there is a possibility that the disease will continue to progress, the original symptoms worsened, and even distant metastasis of the tumor, which will cause pain, cough, wasting and other related symptoms. Goserelin is mainly a targeted drug that can treat breast cancer and prostate cancer, with the effect of killing tumor cells. If drug resistance occurs, its role in killing tumor cells will be weakened, which will lead to continued progression of the disease and aggravation of the original symptoms. Patients in the middle and late stages may have systemic metastasis, such as bone metastasis with pain, lung metastasis with hemoptysis, dyspnea, coughing and so on. Patients with advanced tumors may also show systemic symptoms, such as cachexia, emaciation, loss of appetite, anemia, fatigue, dizziness, nausea, diarrhea and so on. If drug resistance occurs, it is recommended to consider changing drugs for treatment under the guidance of oncologists to control disease progression in time.