Clinically, there is no such thing as what vaccines are most likely to cause high fever in babies; babies can have a high fever reaction to any vaccine. Vaccines as antigens into the body will produce an immune response, so there may be a high fever. Babies are generally at risk for high fever reactions with all vaccines, and each baby reacts differently to vaccines. Any vaccine, which is actually a pathogenic microorganism that has been processed, produces a high fever that is not a disease state but an immune response, so it may occur with either vaccine, mainly related to the baby’s own body state. If the baby develops a strong immune response, a febrile reaction may occur. If your baby has a high fever from vaccination, it is recommended to go to the hospital in time and take medication under the doctor’s guidance.