Enlarged mesenteric lymph nodes in children may be caused by gastrointestinal diseases such as acute mesenteric lymphadenitis, which is usually treated by oral medication after the cause is clarified. Acute mesenteric lymphadenitis is usually secondary to respiratory or gastrointestinal infections, and is characterized by abdominal pain around the umbilicus or in the right lower abdomen, which may be accompanied by fever, nausea, vomiting, diarrhea and other symptoms. Anti-infective treatment is usually needed, and can be treated with oral medication such as cefixime and cefdinir. Tuberculous mesenteric lymphadenitis with ileocecal involvement is common, and children often present with persistent low-grade fever, persistent vague pain in the umbilicus or right lower abdomen, etc. Anti-tuberculous treatment with isoniazid, rifampicin, pyrazinamide, etc. is required. It is recommended that children with swollen mesenteric lymph nodes and stomach pain consult a doctor in time to identify the cause of the disease, and then actively cooperate with the treatment. The above drugs should be used according to the doctor’s instructions.