At present, the causes of osteosarcoma have not been fully clarified, and it is generally believed that it may be related to genetic factors, gene mutation, trauma and so on. 1. Genetic factors: clinical statistics show that if there are patients with osteosarcoma in the family, the risk of osteosarcoma in this family will increase compared with that of ordinary people, and the mechanism is not yet completely clear. 2. Gene mutation: in the process of gene fragment replication, if it is interfered by virus or other factors, it can lead to the failure of normal replication or gene fragment deletion, etc. Some researches have shown that gene mutation can also increase the risk of osteosarcoma significantly. 3. Trauma: Clinical data show that about 10%~30% of patients have a history of trauma or even fracture before the formation of osteosarcoma, therefore, it is currently believed that there is a certain correlation between trauma and the development of osteosarcoma. Therefore, the etiology of osteosarcoma is not clear at present, and it is mostly considered to be related to heredity, gene mutation and trauma, etc. If osteosarcoma occurs, it is necessary to consult the doctor in time and cooperate with the physician for active treatment.