Growth hormone basic information (1) A polypeptide secreted by the anterior pituitary gland, consisting of 191 amino acids, the most important growth-promoting hormone in human beings after birth.
(2) Molecular weight: 22 KD. (3) Characteristics: Secreted in a pulsatile manner.
(4) Frequency: at intervals of about 3 to 5 hours.
(5) Peak: Secretion reaches its peak one hour after sleep, and the amount of secretion is more than half of the total amount of the day. (Peak secretion: 22:00 p.m. – 2:00 a.m.).
(6) Recombinant human growth hormone: Growth hormone made by recombinant DNA technology (E. coli secretory expression technology), abbreviated as RhGH. Physiological effects of growth hormone I. Promote growth and regulate bone metabolism (1) Stimulate chondrocyte differentiation and proliferation at the epiphysis, thus promoting bone growth and increasing bone length.
(2) It can directly stimulate the metabolism of osteoblasts and play an important role in maintaining bone mineral content and bone density.
(3) Cooperate with sex hormones and calcitonin to intervene in bone remodeling.
Regulation of substance metabolism (1) Promote protein synthesis and correct negative nitrogen balance.
(2) Regulate lipid metabolism, reduce body fat reserves, increase serum fatty acid content, reduce serum cholesterol and low-density lipoprotein levels.
(3) Decreases cellular sensitivity to insulin, reduces glucose utilization by peripheral tissues, and raises blood glucose.
(4) It has important effects on water and mineral metabolism.
Other effects (1) Increase the immunity of the body, stimulate immunoglobulin synthesis, and promote the proliferation of macrophages and lymphocytes. (Used before and after liver transplantation).
(2) Accelerate wound healing, stimulate collagen synthesis by fibroblasts in burn wounds and surgical incisions. (Application to burns).
(3) Promotes myocardial protein synthesis, increases myocardial contractility and reduces myocardial oxygen consumption. (Used before and after cardiac surgery).
(4) Promotes luteinizing hormone and follicle-stimulating hormone production (for infertility).