Hypothalamus and pituitary function or target cells without response to growth hormone can cause growth hormone deficiency, resulting in growth lag in children.
1.Organic lesion: Any lesion involving hypothalamus or anterior pituitary gland can cause growth hormone synthesis and secretion disorder.
(1) Intracranial tumors: common ones are hypothalamic tumors, pituitary adenomas and gliomas, etc.
(2) Radiation injury: Occurs after radiation therapy for intracranial tumors or acute leukemia brain.
(3) Head trauma: Commonly occurs in birth injury, such as pituitary stalk injury after breech delivery or forceps assisted delivery, surgical injury or skull base fracture, among which birth injury is the most important cause of domestic children with growth hormone deficiency.
(4) Intracranial infection: such as encephalitis, meningitis, etc.
2. Idiopathic: Children with hypothalamus and pituitary gland do not have obvious lesions, but the cause of GH secretion deficiency is unknown. Some are due to defects in the neurotransmitter-neurohormone pathway, and some are caused by genetic factors, such as defects in the human growth hormone gene.
3.Transient: The child suffers from trauma due to adverse stimulation in the family environment and thus has low growth hormone secretion function, which can be recovered after the external adverse factors are eliminated.