Growth hormone deficiency is a disorder of growth and development caused by partial or complete deficiency in the synthesis and secretion of growth hormone (GH) in the anterior pituitary gland, or by structural abnormalities of GH or receptor defects. It is characterized by lower growth rate than normal children, delayed puberty, and proportional dwarfism.
Idiopathic short stature Individual height is more than 2 standard deviations below the average of the normal group with the same age and sex, and there are no systemic, endocrine, nutritional diseases or chromosomal abnormalities, familial short stature and somatic delayed puberty development are both in the category of ISS.
Smaller-than-gestational-age infants Birth weight and length are below the 10th percentile or more than 2 standard deviations below the mean weight and length for infants of the same gestational age and sex, or birth weight and length are in the 3rd-10th percentile of the corresponding gestational age in the standardized growth chart. It is now receiving increasing attention internationally. Worldwide surveys have found that, in addition to growth hormone deficiency dwarfism, a large proportion of dwarfism is caused by intrauterine growth retardation, and some of the affected children present with growth lag and growth hormone deficiency; therefore, the cognitive development of these children will also be affected if they are not diagnosed and treated in a timely manner.
Precocious puberty is diagnosed if the development of secondary sexual characteristics occurs before the age of 8 for girls and 9 for boys, or if the first menstruation occurs before the age of 10 for girls. When precocious puberty occurs, due to the early secretion of a large amount of sex hormones, the bone growth is accelerated, the bone age is earlier than the actual age, and the epiphysis will fuse earlier, thus shortening the years of puberty growth.
Congenital ovarian hypoplasia syndrome is caused by the complete or partial absence of one X chromosome in all or part of the somatic cells. It is one of the most common human chromosomal aberrations and is the only completely monosomal disease that survives after birth. Other endocrine diseases such as hypothyroidism and cortical dysfunction can also cause short stature. If you find that your child has symptoms of short stature, go to the endocrine specialist or pediatric specialist for early diagnosis and timely treatment. If you find that your child has symptoms of short stature, you should go to the endocrinologist or pediatrician for examination as soon as possible, so that the diagnosis can be confirmed early and treatment can be provided in time.