Side effects of tacrolimus ointment, mainly include local skin irritation, central nervous system symptoms, infections, tumors, renal lesions, and others. 1. Local skin irritation: burning sensation, itching, pain, pins and needles sensation, skin edema, dry skin, erythema, acne and so on. 2. Central nervous system disorder: it may cause seizures. 3. Infections: e.g. pustulosis herpetiformis, scurvy, osteomyelitis, etc. 4. Tumors: lymphoma, histiocytic carcinoma, squamous cell carcinoma, malignant melanoma, etc., may have some association. 5. Renal lesions: acute renal failure and renal insufficiency in patients with kidney with or without ichthyosis-like erythroderma. 6. Others: abnormal vision, anemia, anorexia, dry mouth, anxiety, arthritis, chest pain, constipation, etc. If you need to use drugs need to find a doctor for examination first, under the guidance of the doctor to use, to avoid their own abuse of drugs.