Creatinine 127μmol/L is a mild increase, whether it is serious or not is related to the cause of its elevation, such as physiological factors or acute mild kidney injury is generally not serious, if it is caused by chronic kidney disease is relatively serious. Creatinine 127μmol/L can be seen in physiological conditions such as strenuous exercise, short-term consumption of large amounts of high-protein food, after adjusting the habits of creatinine can be restored, generally not serious. If the elevated creatinine is due to acute renal impairment, remove the causative factors such as drug intoxication, urinary tract obstruction, etc., the creatinine can generally return to normal, and at this time, creatinine 127 μmol/L is also not serious. However, if the elevated creatinine is caused by chronic kidney disease, such as nephrotic syndrome, chronic glomerulonephritis, lupus kidney, diabetic nephropathy, etc., even if the creatinine is mildly elevated, we should pay attention to it, because most of the chronic kidney disease is incurable, and the creatinine of 127 μmol/L in this case is relatively serious. In this case, creatinine 127μmol/L is relatively serious. If creatinine 127μmol/L occurs, it is recommended to consult a doctor in time to find out the cause of the disease, and follow the doctor’s instructions for active treatment to slow down the progress of kidney disease.