Severe cough needs to be treated according to the respiratory system, digestive system, circulatory system, allergies, etc. Cough suppressing and anti-infective, acid suppression, improving circulation, as well as antihistamine treatment. 1. Respiratory system is the most important cause of cough, including upper respiratory tract infection, pneumonia, bronchitis, etc. Antibiotics such as penicillin and cough suppressants such as dextromethorphan should be used in a timely manner. 2. Digestive system, mainly refers to reflux esophagitis, irritation of the esophagus can lead to coughing, the main use of omeprazole and other acid-suppressing treatment. 3. Circulatory system, such as heart failure can cause cough, the use of digitalis and so on to improve circulation treatment. 4. Allergy can also cause severe coughing and is treated with antihistamines such as loratadine. The specific cause of the disease needs to be clarified after medical examination, and at the same time follow the doctor’s instructions for the use of drugs.