Growth hormone: It is a substance necessary to regulate normal growth of the body from birth to adulthood and is the only hormone that is responsible for the linear growth of the epiphysis. If growth hormone deficiency will cause short stature. And after treatment with growth hormone supplementation, the growth rate is accelerated and catch-up growth occurs.
Thyroxine has a wide range of effects in the body: Thyroxine has a synergistic effect with growth hormone to promote linear bone growth. In fetal and infant life, it has a role in protein synthesis of brain cells and normal development of nerve cells.
Sex hormones: can trigger accelerated growth during puberty, but on the other hand also accelerated epiphyseal maturation, which closes the epiphysis and is the slowing down or stopping of growth.