Sudden stomach pain, nausea and vomiting may be due to indigestion, acute gastroenteritis, gastric ulcer and other conditions, the patient needs to follow the doctor’s instructions for drug treatment, surgical treatment. 1. Dyspepsia: Usually patients can follow the doctor’s instructions to use omeprazole, cimetidine and other drugs to inhibit gastric acid treatment, and can also be used with domperidone, cinitapride and other gastric dynamics of the drug or paroxetine, amitriptyline and other antidepressants treatment. For patients with Helicobacter pylori infection, quadruple therapy is also needed for radical treatment. 2. Acute gastroenteritis: usually patients can follow the doctor’s instructions to use montmorillonite and other intestinal mucosal protection agent treatment, and patients can also be used with bifidobacteria, Saccharomyces boulardii and other vitamin preparations treatment. Patients can also use drugs such as elimination of cardotoxin and loperamide to alleviate symptoms and shorten the duration of the disease. At the same time, some patients need to be treated with antibiotics such as norfloxacin and ciprofloxacin. 3. Gastric ulcer: Usually, patients can follow the doctor’s instructions to use omeprazole, lansoprazole and other proton pump inhibitors, and some patients also need to be anti-Helicobacter pylori treatment through the quadruple therapy. Patients also need to use bismuth potassium citrate, magnesium aluminum carbonate and other gastric mucosal protective agents. If the patient’s condition is more serious, ulcer resection surgery is also needed to avoid recurrence or cancer. It is recommended that patients with sudden stomach pain, nausea and vomiting be treated according to the cause of the disease and in accordance with medical advice.