The first vaccine (Hepatitis B vaccine) in the full moon needs to pay attention to the presence of acute diseases, eczema, jaundice and the mouth of the needle can not touch water within 24 hours. 1. Acute disease: when there is fever, runny nose, cough, suggesting that there may be an infection, it is not recommended to receive the vaccine to prevent further aggravation of the symptoms, the need to suspend the vaccination time, to be better or disappear after the symptoms of the vaccination. 2. Eczema: when there is eczema, vaccination may lead to further aggravation of eczema, need to wait until it subsides before vaccination. 3. Jaundice: full-term babies may have jaundice, and full-term vaccination needs to check the bilirubin situation, normal before vaccination. 4. Cannot touch water within 24 hours: You are not allowed to take a bath on the day of vaccination, and the needle opening cannot touch water within 24 hours to prevent skin itching and infection. If you feel unwell after vaccination, you should consult a doctor in time to avoid adverse consequences.