Chicken skin is also known as perifollicular keratosis, which is mainly related to heredity, dry skin, and abnormal keratinization of the follicular opening. This disease generally does not require treatment, if the patient is self-conscious of the aesthetic impact, then the patient can be oral medication or topical drugs to remove chicken skin on the thighs. 1. Topical drugs: patients can use under the guidance of the doctor, retinoic acid cream, 10% to 20% of the urea cream, 12% ammonium lactate lotion, etc., to play the role of softening and dissolving keratin. 2. Oral medication: Oral medication is suitable for patients with more serious symptoms of chicken skin, such as oral vitamin A, vitamin A acid drugs. For the existence of chicken skin on the thighs of patients, if the self-consciousness affects the aesthetic, it is recommended to go to the regular hospital in time for examination, under the guidance of professional doctors for standardized treatment.