There are more reasons for pain in clenched fist, which may be related to trauma, hand osteophytes, rheumatoid arthritis and so on. 1. Trauma: Pain can be caused when making a fist due to severe impact on the hand or straining of ligaments, muscles and tendons in the hand. 2. Osteomalacia of the hand: if the patient has a history of trauma to the fingers, resulting in destruction or structural change of the cartilage and bone joints of the fingers, increased sensory friction of the finger bones, and osteomalacia. Irritation of local nerves or tissues, pain symptoms will occur when making a fist. 3. Rheumatoid arthritis: joint inflammatory cells in the hand gather and release a large number of inflammatory factors, which can stimulate local nerves and produce pain when the hand makes a fist, and the pain is obvious. Appear to make a fist when pain occurs, it is recommended to seek medical attention in a timely manner, follow the doctor’s instructions for further examination, with the help of the doctor to clarify the cause, and targeted treatment or treatment.