The skin on the soles of the feet is very thick and hard, considering callus, corns, plantar warts, etc. The treatment includes medication, physical therapy, surgical treatment and so on. 1. callus: long time friction and pressure will lead to local thickening of the stratum corneum callus, if it is not particularly serious, do not need special treatment, if you think it affects the appearance of the salicylic acid paste or apply urea cream to make the keratinous relaxation, if the effect of medication is not obvious, but also through physical therapy to remove, including liquid nitrogen freezing, carbon dioxide laser, etc.. 2. corns: foot friction and pressure for a long time, there will be a thickening of the stratum corneum to form corns, there is obvious pressure and pain, you can use the corns cream paste, if the effect is not good, you can through the liquid nitrogen freezing, laser and other physical methods to remove the larger lesions can be carried out corns digging out surgery. 3. metatarsal warts: metatarsal warts are common warts that occur on the bottom of the foot. Human papillomavirus infection of the soles of the feet will cause abnormal overgrowth of the skin of the soles of the feet, become keratinized, rough, and because the skin of the soles of the feet is easy to pressure, friction, trauma, and sweating, so it is manifested in the soles of the feet of the skin extensive keratinization insufficiency, the horny layer is thick and hard. Treatment is based on freezing and laser. There may be other reasons why the skin on the soles of the feet is thick and hard, so we suggest that we go to the hospital in time to improve the examination and clarify the cause of the disease, and then give targeted treatment or treatment. All of the above drugs should be used in accordance with medical advice.