Patients with eye cracks due to different causes, the choice of drugs are different, common causes include blepharitis, eczema, vitamin B2 deficiency, etc., patients can follow the doctor’s instructions to use antibiotics, hormones and vitamins and other drugs treatment. Patients due to the sebaceous glands of the eyelid secretion leads to blepharitis is easy to complicate the infection, gradually aggravated can cause the patient corner of the eye cracks, patients can follow the doctor’s instructions to use antibiotics, such as levofloxacin eye drops, tobramycin ophthalmic ointment. If the patient’s eyes are wet for a long time, easy to complicate eczema, dry season is prone to dry cracks, resulting in cracks in the corners of the eyes, the patient can use glucocorticoid eye ointment treatment, such as tobramycin dexamethasone ophthalmic ointment, etc., to alleviate the symptoms of ocular discomfort. If the patient’s body lacks vitamin B2, there may be bulbar conjunctival congestion, eyelid margin erosion, cracks in the corners of the eyes and other uncomfortable symptoms, the patient can take oral vitamin B2 treatment, to promote the recovery of the condition. It is recommended that patients with cracks at the corners of the eyes should be treated in a timely manner in a regular hospital to assess their condition and follow the doctor’s instructions for treatment.