Tuberculous pulmonary effusion with chest pain after healing is generally not considered to be cancerous, but recurrence of tuberculosis or primary chest tumor cannot be excluded. Tuberculous pulmonary effusion is usually pleural effusion caused by tuberculous pleurisy, which will dissipate after standardized anti-tuberculosis treatment, thoracentesis and drainage or closed thoracic drainage to drain out the excess effusion. There is no evidence that tuberculosis is directly related to the development of cancer, so the possibility of tuberculosis cancer can be ruled out. Chest pain after tuberculosis is cured cannot exclude the possibility of recurrence of tuberculosis, when tuberculosis foci involve pleura, there can be chest pain, i.e. pleural chest pain; primary pleural tumor or bronchopulmonary cancer can also cause chest pain. The causes of chest pain are very diverse and can involve cardiovascular system, respiratory system, etc. We should go to regular hospitals in time, make clear diagnosis and standardize treatment.