Blood tests for lymphoma may show anemia with decreased hemoglobin, elevated eosinophils, and absolute or relative increase in lymphocytes. Lymphomas originate in lymphoid tissues and are mostly associated with malignant changes in certain immune cells produced by the proliferation and differentiation of lymphocytes in the course of the immune response. Lymphomas include Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Blood tests in patients with Hodgkin’s lymphoma often show a decrease in hemoglobin, which manifests as mild or moderate anemia, and some patients have elevated eosinophils. When the bone marrow is extensively infiltrated or hypersplenism occurs, there is a decrease in red blood cells, white blood cells, and platelets. Blood tests in patients with non-Hodgkin’s lymphoma are mostly normal for leukocytes, accompanied by an absolute or relative increase in lymphocytes. The presence of increased blood sedimentation rate and elevated serum lactate dehydrogenase during active disease suggests a poor prognosis. An increase in serum alkaline phosphatase activity or calcium may indicate skeletal involvement.B-cell non-Hodgkin’s lymphoma may be associated with hemolytic anemia, and in a few patients, monoclonal IgG or IgM may be present, and cerebrospinal fluid protein levels may be increased in cases of central nervous system involvement. Patients should not make the diagnosis on their own based on blood tests alone, but should be diagnosed by a doctor after completing relevant tests.