Connective tissue disorders can be incurable for the rest of one’s life, but in some cases, active treatment can relieve symptoms and improve quality of life. Connective tissue disorders are diseases that involve connective tissues and can be caused by genetic, environmental, or pharmacological factors. Common symptoms include joint pain, Raynaud’s phenomenon, skin rashes and erythematous changes. There is currently no cure for the disease, but after diagnosis, patients can improve their quality of life with standardized treatments to alleviate the symptoms. Medications include non-steroidal anti-inflammatory drugs, such as diclofenac and celecoxib; glucocorticosteroids, such as prednisone and methylprednisolone; and anti-rheumatic drugs, such as methotrexate, leflunomide and cyclophosphamide. It is recommended to use drugs under the guidance of a doctor. If the disease is more serious and joint damage occurs, it is necessary to take surgical treatment surgery in conjunction with the condition, including synovectomy, joint orthopedic surgery and joint replacement surgery. It is recommended that patients with connective tissue disease go to the hospital in time to avoid delays.