In neurosurgery, cranial defects are becoming more and more common, such as falling objects, traffic accidents, etc., can lead to cranial defects, and some cranio-cerebral surgery is often left behind after cranial defects. After a skull defect, the intracranial tissues have no external protection, and may be attacked by the outside world at any time, which will affect the whole organism. Cranial defects are a matter of life and health, patients should not have a fluke mentality, and do not think that the defective parts will grow well and heal by themselves, once it occurs, we should pay attention to it, especially for patients with cranial defects larger than 3cm in size, strictly speaking, we should go to the hospital in time to do cranial bone repair surgery, so that we can regain a closed and stable cranial cavity environment as soon as possible. Of course, it is very important to do cranial bone repair surgery is the choice of material, material selection is good postoperative recovery will be better. Calcium phosphate cranial bone repair material is good? Many patients are inquiring about this question, but in fact, calcium phosphate is a more traditional repair material, with bone cement and plexiglass, etc., because of the poor clinical results, has been slowly eliminated. Now more commonly used is titanium mesh material, which is much more advanced than the previous material, but because it is a metal material, coupled with the use of a cover type of repair, there will be a lot of problems and shortcomings after the operation, and there is a risk of exposure of the material. In fact, in comparison, it is safer and more appropriate to do skull repair surgery or our team now widely used new polyetheretherketone peek material. The peek material has high hardness and strength, good stability, is very close to the autologous skull, and has high postoperative comfort and protection. Moreover, we have introduced the concept of cosmetic surgery into the operation, which not only can highly restore the anatomical structure of the skull, but also provides a beautiful and natural effect after the operation.