Pus in the patient’s lower eyelid may be caused by granuloma. There are a lot of blepharoplasty glands inside the lower eyelid, bacteria may enter the gland and cause inflammation. Bacteria reproduce in large quantities in the gland and produce secretions, and these secretions can not be discharged through the mouth of the gland in a timely manner, and pus can be formed by accumulating in the gland, which is clinically referred to as wheal, or also called blepharitis. When a patient develops a wheal, he or she should seek medical treatment in a timely manner and use antibiotics such as tobramycin eye drops and erythromycin ophthalmic ointment under the guidance of a doctor to control the inflammation. If the abscess is large, patients can be surgically incised and drained so that the pus can be discharged and the abscess can be promoted to subside. Usually patients should also pay attention to the hygiene around the eye to avoid aggravation of the infection. It is recommended that patients with granuloma seek timely medical attention to assess their condition and follow the doctor’s instructions.