When the proliferative foci of lung nodules increase in size, the specific treatment plan first determines the cause of the corresponding condition, and the common clinical causes include peripheral inflammation, recurrence of tuberculosis, and tumor formation, and the treatment plan includes anti-infective treatment, anti-tuberculosis treatment, and surgical resection. 1. Inflammation: Inflammation will occur around some of the proliferative foci, leading to an increase in the scope of the corresponding foci, which can be treated with regular application of anti-inflammatory drugs (cefixime, etc.), and then changes can be observed. 2. Tuberculosis recurrence: some of the proliferative foci belong to the residue of tuberculosis after absorption, and the recurrence of tuberculosis under the condition of decreased immunity of the body will also lead to the enlargement of the foci, which can be further treated with anti-tuberculosis, and commonly used drugs include isoniazid and rifampicin. 3. Tumor formation: a small portion of patients will have peri-scar cancer, which will lead to the corresponding condition and need radical resection through surgery. Once the proliferative foci of lung nodules increase in size and are accompanied by the formation of surrounding soft tissue masses, chest pain, cough and other symptoms, it is necessary to consult a doctor in time for observation and standardized treatment under the guidance of clinicians.