Herpes simplex virus type 2 antibody negative means that you are not infected with herpes simplex virus type 2. Herpes simplex virus (HSV) often causes localized lesions through infections of mucous membranes, skin, and nerve tissues, and includes two subtypes: HSV-1 and HSV-2. HSV-1 mainly causes infections of the skin and mucous membranes of the skin and the central nervous system, and is most commonly seen in children, while HSV-2 mainly infects skin and mucous membranes of the genital area and newborns, causing genital herpes. HSV infection can produce antibodies, including IgM and IgG, with IgM indicating recent infection and IgG suggesting previous infection. HSV can infect the fetus through the placenta, resulting in fetal malformations and miscarriage, so herpes simplex virus antibody testing is needed to screen for infection in preparation for conception, during pregnancy, and in the presence of symptoms of related infections. Negative herpes simplex virus type 2 antibodies indicate no herpes simplex virus type 2 infection, and the clinical significance varies depending on the type of antibody, so consult your primary care physician.