There is no such thing as the fastest and most effective way to treat calf numbness. Numbness of the calf needs to be clearly identified after the cause of the cause of treatment, common diseases are diabetes, neuritis, lumbar disc herniation, etc., need to be treated with medication and surgical treatment. 1. Diabetes: diabetic patients may have small blood vessel embolism, blood stasis, nerve edema, etc., in which case calf pain and numbness often occur, diabetes-induced calf pain and swelling need to be treated for diabetes, oral metformin drugs, such as metformin, etc., to control blood sugar. 2. Neuritis: the most common symptoms of neuritis are numbness of the hands and feet, muscle atrophy, muscle weakness, etc. Neuritis is often aseptic inflammation, you can take neurotrophic drugs, such as vitamin B, methylcobalamin tablets, for the pain symptom, you can take oral non-steroidal anti-inflammatory drugs, such as celecoxib. 3. Lumbar disc herniation: lumbar disc herniation serious patients will have intravertebral compression, in this case the nerve root is compressed, will lead to lower limb numbness, soreness, there is compression of the nerve control area, there will be extensive muscle weakness, atrophy, etc., it is recommended that early surgical treatment, the use of intervertebral foraminal nucleus pulposus removal, decompression, relief of symptoms. The above drugs need to be used under the guidance of a doctor.