Adults with a very serious cough and keep coughing need to be treated according to the cause of the disease, the common causes of the disease are generally variant asthma, drug-induced and tuberculosis, etc., the treatment method is to avoid allergens, stop using drugs that cause coughing or take anti-tuberculosis drugs and so on. 1. Variant asthma: often caused by contact with allergens, cough may be very serious, generally need to find allergens, avoid allergens, while using drugs, such as salbutamol aerosol, budesonide powder inhaler and other treatments, usually can be significantly relieved. 2. Drug-induced cough: some drugs can cause cough, such as captopril, etc., should stop taking such drugs in time, and use other classes of antihypertensive drugs. 3. Tuberculosis: Tuberculosis patients can be manifested as severe cough, afternoon low fever, night sweats, etc., the need for active anti-tuberculosis treatment, such as isoniazid, rifampicin, ethambutol. Adults with a severe cough that doesn’t stop coughing may have other causes, such as mycoplasma pneumonia, bronchitis, and so on. You should go to the hospital in time, the doctor according to the specific condition and auxiliary examination to determine the cause of the disease to give timely treatment. The above drugs need to be applied under the guidance of a doctor.