Dry and cracked hands and feet may be related to physiological factors, such as environmental dryness, etc.; it may also be related to pathological factors, common diseases such as chronic eczema, tinea versicolor. Anti-allergic drugs or antifungal drugs can be applied for treatment. 1. Physiological factors: cracked hands and feet may be due to environmental dryness, often use alkaline detergents and other physiological factors, you can use Vitamin E urea cream and other drugs to moisturize the skin due to dryness of the flaking, cracking, etc. has a very good role in alleviating. 2. Pathological factors: (1) chronic eczema: if the hands and feet are dry and cracked due to chronic eczema, often accompanied by local thickening, itching and other symptoms. Patients can use strong glucocorticoid ointment externally, such as halometasone cream, etc.; oral antihistamines, such as loratadine, etc. for treatment. (2) tinea pedis: often caused by fungal infection, especially keratinized scaly tinea pedis can lead to flaking hands and feet, skin thickening, cracking and so on. Patients can use external ketoconazole cream, clotrimazole cream and other drugs for treatment, can also use salicylic acid ointment to soften the keratin. When patients have dry cracked hands and feet, should be under the guidance of a professional doctor, according to the cause of the selection of targeted drug treatment.