Mesenchymal tumor is a mesenchymal tumor originating in the wall of the gastrointestinal tract, and is normatively called gastrointestinal mesenchymal tumor. Tumors originating from mesenchymal tissue of the GI tract, stem cells with multidirectional differentiation potential and potentially malignant biological behavior, occur anywhere in the GI tract, but most often in the stomach. Mesenchymal tumors of the gastrointestinal tract are becoming recognized with the development of pathological techniques and are the most common mesenchymal-derived tumors of the GI tract. The risk grading criteria for mesenchymal tumors are based on the size of the tumor and the number of nuclear divisions. The age of onset of the disease is mostly middle-aged and elderly people aged 50-70 years. Clinical symptoms are variable, ranging from asymptomatic to non-specific gastrointestinal discomfort, abdominal pain, and masses. Clinical manifestations are related to tumor size, site of occurrence in relation to the gastrointestinal wall, benignity and malignancy. The disease is often detected during electrogastroscopic enteroscopy or CT examination. Early interventional treatment is important in the treatment, and surgical resection remains the preferred method of treating mesenchymal stromal tumors.