Jaundice detection in newborns needs to be based on specific bilirubin levels, high-risk factors to determine the frequency of review, such as higher bilirubin levels can be 1 to 2 times a day, or even need to review liver function if necessary, and lower can be 2 days once percutaneous measurement of bilirubin levels, or even more long time to monitor a time. Bilirubin levels in newborns are recommended to be determined according to the zonal curve of bilirubin values at day or hour of age of the newborn. Common risk factors include prematurity, neonatal hemolysis, subcutaneous bruising, asphyxia, hypoxia, hyperthermia, hypothermia, hypoglycemic acidosis, and sepsis. Taking the above conditions into consideration, if the bilirubin level measured in the newborn is higher than the range of Bhutani curve, it can be monitored percutaneously once a day. If it is higher or combined with risk factors such as preterm labor, it can be monitored twice a day if necessary, and for babies who need blood exchange therapy, it is even necessary to repeat blood sampling to review the liver function to understand the bilirubin level. If the bilirubin level is low and there are no risk factors, etc., it can be monitored once every 2 days or even longer, which can be evaluated and handled under the guidance of neonatologists.