Pituitary prolactin high consider the possible existence of hyperprolactinemia, may be physiological, drug factors, such cases caused by hyperprolactinemia can be restored; may also be pituitary diseases and other factors, such cases after treatment most of the amenorrhea can be restored, it is recommended to follow the doctor’s instructions for treatment. One of the common causes of hyperprolactinemia is pituitary disease, which can be treated with bromocriptine mesylate to inhibit the secretion of pituitary prolactin and inhibit the proliferation of prolactinoma cells, so as to achieve the therapeutic purpose; if it is a pituitary tumor caused by hyperprolactinemia, it is necessary to consider surgical resection treatment. After active treatment, most patients’ blood prolactin level can be normalized, and amenorrhea patients can resume menstruation. In addition, hyperprolactinemia can also be seen in menstruation, pregnancy and other physiological state, as well as after taking risperidone, Sulpiride and other drugs, physiological factors caused by the self-recovery, drug factors caused by the discontinuation of the drug can be restored. Once prolactin is restored, the patient’s amenorrhea can also return to normal. In the case of elevated prolactin with amenorrhea, it is recommended to go to the hospital after eliminating physiological factors.