Nausea, regurgitation, vomiting, headache and fatigue may be due to intracranial lesions, as well as digestive system diseases and systemic diseases. 1. Intracranial lesions, such as cerebral hemorrhage, intracranial infection, venous sinus thrombosis and other diseases, may lead to increased intracranial pressure, which in turn leads to the above series of symptoms. 2. Digestive system diseases, such as gastritis, gastroesophageal reflux disease, etc., which may begin to manifest as digestive symptoms, nausea, vomiting, and in severe cases, headache and fatigue. 3. Systemic diseases, such as electrolyte disorders, cardiac insufficiency, hyperthyroidism, anemia, etc., may also show similar symptoms. Nausea, regurgitation, vomiting, headache, fatigue, there may be other causes, it is recommended to go to the internal medicine or neurology, under the guidance of a professional physician to clarify the cause of the disease and give targeted treatment.