Treatment for schizophrenia simplex includes medication, psychotherapy, and physical therapy. 1. Medication: Patients with schizophrenia can be treated with second-generation antipsychotic medications, such as quetiapine and olanzapine, which are effective for both negative and positive symptoms, and can improve cognitive function. 2. Psychotherapy: such as cognitive behavioral therapy, to improve the patient’s ability to work and life, but also family intervention, family members to understand and reassure the patient, the patient should also adjust the psychological state. 3. Physiotherapy: In the course of drug therapy and psychotherapy, some physiotherapy can also be carried out, such as repeated transcranial magnetic stimulation or electroconvulsive therapy, all of which have certain effects. In the process of treatment, should follow the doctor’s instructions for safe and reasonable use of drugs, do not use drugs indiscriminately, and should be regular medical review.