High serum direct bilirubin can be seen in obstructive jaundice, hepatocellular jaundice, hemolytic jaundice and so on.
1. Obstructive jaundice: refers to the jaundice caused by the obstruction of bile duct. As the flow of bile into the duodenum through the bile duct is blocked, which leads to the increase of pressure in the bile duct, the bile enters the hepatic sinusoids through the hepatocytes and capillary bile ducts and enters into the bloodstream, which leads to the elevation of serum direct bilirubin and causes jaundice.
2. Hepatocellular jaundice: refers to jaundice caused by impaired function of hepatocytes. As the metabolism of bilirubin in the human body must rely on the liver’s uptake, transformation and excretion, when the hepatocyte hepatocyte function is impaired leading to bilirubin metabolism disorder, which causes jaundice due to the elevation of serum direct bilirubin.
3. Hemolytic jaundice: due to the destruction of a large number of erythrocytes, a large amount of bilirubin is formed, which exceeds the ability of liver cells to ingest, transform and excrete, thus causing jaundice with elevated serum bilirubin, and its elevation is mainly dominated by the elevation of indirect bilirubin, which can also cause the elevation of serum direct bilirubin.
There are many other causes of high serum direct bilirubin, which should be emphasized, and timely consultation should be made to find out the cause of the disease, and further treatment or therapy should be prescribed by the doctor.