Appendicitis surgery in pregnant women does not usually lead to infant malformations, and there is no direct link between the two. Appendicitis in pregnant women is a special type of appendicitis. Clinically, due to the enlargement of the pregnant woman’s uterus causing the appendix and appendix to move to the right upper abdomen, the large omentum does not easily wrap around the inflammation, which makes clinical diagnosis difficult and can easily lead to miscarriage. Once the diagnosis is clear, surgery should be the main treatment for both early and late pregnancy, and progesterone can be used to protect the fetus during the surgery period. The clinical formation of appendicitis is related to fecal stone impaction and bacterial invasion, which is not directly related to pregnancy. Infant malformation is mainly caused by defects in the fetal development process itself, appendicitis will not affect fetal development, but the inflammation will affect the stability of the uterus, leading to uterine contraction causing miscarriage, but will not lead to fetal malformation.