Short-term use of hormone medications has no effect on the liver; prolonged use does have an effect on the liver. Hormonal drugs are widely used in clinical practice and are commonly used to treat hormone deficiencies. There is no effect on the liver when hormonal drugs are taken in the short term. Commonly used hormone drugs such as pregnenolone, prednisone, dexamethasone and other drugs are harmful to the liver when taken for a long period of time and should not be taken for a long period of time. When different diseases are treated with different hormone drugs, reasonable medication is generally not affected by the liver, long-term use may cause liver function damage. When the liver function is abnormal, it is also necessary to timely treatment to restore liver function, maintain normal internal balance to promote digestion and restore health. When the patient is using drugs, should be under the guidance of the doctor to take medication, to avoid leading to adverse effects.