China has a large number of hypertensive people, with statistics exceeding 300 million, which means that almost one-third of the population suffers from hypertension or has a blood pressure that exceeds the normal high value. There is a close causal relationship between the level of blood pressure and the risk of cardiovascular disease and death. Therefore, in clinical practice we refer to hypertension as a “cardiovascular syndrome”. The fundamental goal of hypertension treatment is to reduce the overall risk of cardiovascular, cerebrovascular, renal and vascular complications of hypertension and death. Therefore, in the prevention of cardiovascular and cerebrovascular disease and reduce cardiovascular and cerebrovascular risk of the treatment process, antithrombotic plays an important role, and aspirin is the most commonly used antithrombotic drugs in the clinic. First, the role of antithrombotic drug aspirin in hypertensive patients The role of antiplatelet drugs (aspirin, etc.) in the secondary prevention of cardiovascular and cerebrovascular diseases has been confirmed by a large number of clinical studies, which can effectively reduce the risk of cardiovascular events by 19% to 25%, of which non-fatal myocardial infarction decreased by 1/3, non-fatal stroke decreased by 1/4, and fatal vascular events decreased by 1/6. the following patients with hypertension should be active Antiplatelet therapy: ① Hypertension combined with atherosclerotic heart disease patients, need to apply small-dose aspirin for long-term secondary prevention; ② combined with acute attacks of thrombosis, such as acute coronary syndrome, ischemic stroke or transient cerebral ischemia, occlusive peripheral arterial atherosclerosis, should be used in accordance with the recommendations of the relevant guidelines for a variety of anti-thrombotic drugs. The benefit of aspirin therapy for primary prevention of cardiovascular and cerebrovascular diseases is mainly reflected in the cardiovascular high-risk risk groups, such as hypertension with diabetes mellitus, hypertension with chronic kidney disease, 50-69 years old cardiovascular high-risk people (10-year total cardiovascular risk ≥ 10% or hypertension combined with 3 or more other risk factors), can be used for primary prevention with a small dose of aspirin. Second, the long-term application of aspirin in hypertensive patients The long-term application of aspirin in hypertensive patients should pay attention to: ① need to be started after the blood pressure control is stabilized (<150/90mmHg). Do not achieve good control of hypertension (blood pressure is too high), aspirin may increase the risk of cerebral hemorrhage; ② enteric-coated aspirin is recommended to be taken on an empty stomach in order to reduce gastrointestinal reactions (remember to enteric-coated tablets should be taken on an empty stomach in order to protect the stomach); ③ before taking the high risk of gastrointestinal bleeding, such as gastrointestinal disorders (history of ulcer disease and its complications), 65 years of age or older, and the simultaneous use of corticosteroids, anticoagulants, or non-steroidal anti-inflammatory drugs, etc. Preventive measures should be taken, including screening and treatment of Helicobacter pylori infection, prophylactic application of proton pump inhibitors, as well as the use of a rational combination of antithrombotic drugs program, etc.; (4) People with the combination of active gastric ulcer, severe liver disease, renal failure, bleeding disorders need to be careful with the use of or discontinue the use of aspirin; (5) people who are taking aspirin and experience severe gastrointestinal bleeding discontinue the use of aspirin, and deal with it in accordance with the pathway related to bleeding, the Mild cases can be treated with additional acid-suppressing and stomach-protecting preparations.