Slightly thickened appendix and slightly enlarged multiple lymph nodes in the mesenteric region may be due to acute enteritis, acute appendicitis and other factors. 1. Acute enteritis: Acute enteritis is mainly a series of syndromes that occur in the intestinal tract as a result of acute infection, producing an inflammatory response, so the peripheral drainage of inflammation may lead to the appearance of a slightly thickened appendix, and the mesenteric region of multiple lymph nodes slightly enlarged phenomenon. 2. Acute appendicitis: Acute appendicitis is mainly caused by the obstruction of the appendiceal lumen due to the lymphatic tissues in the intestinal wall, stones in the intestines, etc., and the emergence of infections leads to the inflammation and swelling of the appendix, which may be accompanied by the enlargement of lymph nodes, and so there will be a slight thickening of the appendix and a slightly enlarged multilobulated lymph nodes in the mesenteric area. If the patient appears appendix slightly thick, mesenteric lymph nodes slightly enlarged, it is recommended to go to the hospital in time for examination, under the guidance of the doctor to clarify the cause of the disease and actively carry out targeted treatment, to avoid delaying the aggravation of the condition.