The nodules that form in the late stages of granuloma do not go away on their own. The nodule in the late stage of wheal is usually formed locally after the acute stage, this nodule will last for a long time, and there is the possibility of recurrent infection, usually can not be eliminated by itself, and need to be surgically removed from the cystic wall of the wheal in order to achieve the purpose of healing. For the late drop of hard nodules is to surgically remove the cystic wall of the granuloma, to ensure that after the removal of the cystic wall of the leptomeningeal gland, there is no local inflammatory stimulation, to prevent recurrent infections. After the surgery, it is important to pay attention to the hygiene around the eyes and avoid spicy and irritating foods during the treatment. When the patient has a late stage of wheal that falls hard knot, please seek medical attention in time, under the guidance of the doctor for treatment.