In recent years, with the development of lung cancer molecular biology research, molecularly targeted drugs have become a new treatment option for advanced non-small cell lung cancer (NSCLC). There are many major targets of targeted therapies for NSCLC, but the most studied ones are epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF). The most studied EGFR pathway targeted therapeutics approved for clinical use include gefitinib (trade name: ERSA), erlotinib (trade name: Troche) and cetuximab (trade name: Epiduo), while the VEGF pathway targeted therapeutics are mainly bevacizumab. The introduction of targeted therapies has made it possible for lung cancer patients to “live with tumor”. However, patients with this disease may experience different degrees of adverse effects during the long-term use of targeted therapies. The following are the most common adverse reactions and TCM treatment for lung cancer patients undergoing targeted therapy. 1. Rash Lung cancer patients may have different degrees of rash after taking targeted drugs for 7 to 10 days. It is manifested as rice-sized herpes on the lips, cheeks, back and buttocks, or even inflammation, pus and intolerable itching. Patients with severe rash can apply chloramphenicol, jeramycin, Bactrim and other western medicines on the affected area, and can also use topical Chinese medicine Furfuryl Glycolate, or prescribe: 9g each of bitter ginseng, red peony, dahurica, wild chrysanthemum, honeysuckle and zingyandian. 2.Diarrhea Patients with lung cancer may have different degrees of diarrhea after taking targeted drugs. If the diarrhea is mild, no treatment is needed; if the diarrhea is severe, anti-diarrheal drugs (such as Emmenagogue) can be used for symptomatic treatment. The basic formula is Ginseng and Atractylodes macrocephalus, with the addition of horsetail and fructus herb for heat toxicity; the addition of dandruff and elm for clearing heat and cooling the blood; the addition of eucommia and dried ginger for spleen-yang deficiency and yin-cold deficiency; and the combination of tonifying and benefiting qi soup for those with prolonged diarrhea and evidence of middle qi subsidence. 3.Interstitial pneumonia A few patients develop acute pneumonia, interstitial pneumonia and lung injury after taking targeted drugs. The main symptoms are cough, chest pain, coughing and spitting yellow sputum, shortness of breath, fever, and in severe cases, respiratory distress. Chinese medicine treatment is recommended to sweeten and cool the earth to nourish Yin, moisten the lung and clear heat. Commonly used drugs: Radix Salviae Sinensis, Radix et Rhizoma Ginseng, Radix Maitake, Asparagus, Lily, Radix Scutellariae Sinensis, Radix Scutellariae Sinensis, Mulberry Peel, Golden Buckwheat, Fritillariae Sinensis, Radix Chrysanthemum, Almond, Radix Platycodon, etc. In case of hemoptysis, Xian He Cao, Bai He, Hua Rui Shi and Ginseng San Qi can be added as appropriate. It should be noted that lung cancer patients must use targeted drugs under the guidance of doctors, and the dosage should be reduced or discontinued under the guidance of doctors in case of adverse reactions. In case of serious adverse reactions, a professional physician must be consulted for emergency treatment, otherwise the disease will be delayed and can lead to death in serious cases.