Cephalosporin antibiotics and levofloxacin which effect is not conclusive, need to be specific depending on the type of infection and the patient’s situation, should be used under the guidance of a doctor. Cephalosporin is a large class of drugs, belonging to the β-lactam antibiotics, can inhibit the synthesis of the bacterial cell wall to produce antibacterial effect, antibacterial spectrum, strong bactericidal force. It is effective against Gram-positive and Gram-negative bacteria, and can be used to treat respiratory tract, urinary tract, skin and soft tissue infections caused by sensitive bacteria. Cephalosporins should not be used in people who have a history of allergy to such drugs, and should not drink alcohol within 3 days of use to avoid “disulfiram”-like reactions. Allergic reactions such as skin rash, itching, vomiting, diarrhea, leukopenia and other adverse reactions may occur after use. Levofloxacin is a kind of quinolone, which can inhibit bacterial DNA replication, transcription and other processes to play an antibacterial role. It has a wide antimicrobial spectrum and strong antimicrobial activity. It can be used for the treatment of respiratory tract infections, skin and soft tissue infections, pyelonephritis, etc. caused by sensitive bacteria. Levofloxacin should not be used in people who are allergic to quinolones, nor should it be used in pregnant and lactating women and patients under 18 years old. Its use may cause insomnia, headache, nausea, diarrhea, and even adverse reactions such as tendonitis, tendon rupture, worsening of myasthenia gravis, and hypersensitivity reactions. In summary, which of these two drugs is more effective is not absolute, the doctor will choose the appropriate antibacterial drug according to the type of infection, the patient’s condition, it should be used in accordance with the doctor’s instructions, do not blindly use the drug.