Total bilirubin value between 3.4-17.1mg/dl, within this range is normal, total bilirubin 21 than the normal value is slightly higher than the normal value, although it is an abnormal result, but does not necessarily have a pathological significance, such as a persistent increase or coexisting liver and bile and other parts of the disease, should be considered as a pathology. Elevated total bilirubin is mostly caused by diseases of the hepatobiliary system, especially obstruction of the biliary system, and is also susceptible to secondary infections, with elevated total bilirubin and direct bilirubin as the main cause. However, for patients with liver disease, hepatocellular jaundice can have elevated total bilirubin and indirect bilirubin, and patients may also have abnormal liver function such as elevated transaminases. At this time, the treatment should be directed at the cause of the disease, commonly found in chronic viral hepatitis, can choose antiviral therapy, but also the use of bisabolol, silymarin and other hepatoprotective symptomatic treatment. Patients with obstructive jaundice should be treated with anti-infection for secondary infections and timely surgery to relieve obstruction if necessary. If the total bilirubin is persistently increased, the patient should consult the doctor in time to clarify the specific cause and follow the doctor’s instructions.