Statistics show that the incidence of gallbladder polyps in the domestic population is 5.0% to 9.5%. Since some polyps have the potential to become cancerous, some patients are panic-stricken and are eager for surgical treatment. The detection rate, annual incidence and long-term changes of gallbladder polyps in a fixed population with regular long-term checkups and some patients after surgery are reported below for clinical reference. Among 8,474 patients in the relatively regular population of the hospital physical examination center, 486 patients with gallbladder polyps were detected, with a detection rate of 5.74%. 3 cases were missed, 41 cases were treated surgically, 1 case of polyps disappeared, and the remaining 441 cases were observed for 5 years. The detection rate of gallbladder polyps at different ages and the occurrence of polyps diameter and multiple polyps at 5 years were compared. Results: 1. After 5 years of observation, the maximum diameter of polyps did not increase significantly in 441 patients with gallbladder polyps, and the condition was stable; the increase in the incidence of multiple polyps may be related to the type of polyps, i.e. most of them were cholesterol polyps (cholesterol polyps are often manifested as multiple, benign lesions, and the possibility of cancer is very small). There was only one case of gallbladder cancer, which was highly suspected to be gallbladder cancer after preoperative examination, and there was no evidence of malignant transformation from benign polyps, and it was more likely that the primary was gallbladder cancer. The results of this study also proved that the majority of PLG patients are in stable condition and long-term observation is sufficient. 2. Laparoscopic cholecystectomy, which is rapidly becoming popular, has become the “gold standard” for the treatment of gallbladder polyps, but many complications occur after cholecystectomy, such as dyspeptic diarrhea, gastric reflux of duodenal fluid and esophageal reflux of gastric fluid, bile duct injury, common bile duct stones, colon cancer, etc., which seriously affect the quality of life of patients. For biliary surgery, the most important concern is the recurrence of polyps or gallbladder stones after surgery. In this study, there was only one postoperative recurrence and one postoperative gallstones (considered as postoperative complications) in 11 patients in 5 years. Xuan Xingtie et al. followed up 40 patients with minimally invasive biliary polyps for 1 to 3 years and did not see any recurrence of polyps, which is similar to this study.