In some cases a minute to see the effect of painkillers is true, such as lidocaine and other local anesthetic drugs may be able to achieve analgesia in one minute for some diseases, but not effective in all cases; non-steroidal anti-inflammatory analgesics, opioids usually can not be effective in one minute; need to be in the etiology of the cause of the selection of the appropriate analgesic drugs to achieve the effect of pain relief. 1. Local anesthetic drugs: including lidocaine, bupivacaine, ropivacaine, etc., may be able to achieve the effect of analgesia within one or two minutes, mainly used for local surgical pain, surgical acute traumatic injury disposal of pain, labor pain relief. However, it should be noted that infants, pre-excitation syndrome, severe conduction block and other prohibited use. 2. Non-steroidal anti-inflammatory analgesics: including ibuprofen, celecoxib and other drugs, its onset of action time is related to the disease and the drug, but usually can not be effective within one minute. The drug can be used for the relief of joint pain, toothache, muscle pain, neuralgia, menstrual cramps and so on. However, it should be noted that peptic ulcer, abnormal liver and kidney function, pregnant women and lactation and other conditions are prohibited. 3. Opioids: weak opioids such as tramadol and strong opioids such as morphine, which usually cannot take effect within one minute. Weak opioids can be used in the treatment of cancer pain, fracture pain, postoperative pain, etc. Strong opioids are mainly used in the treatment of cancer pain. However, it should be noted that it is contraindicated in liver and kidney insufficiency, lactation and pregnancy. The above drugs must be used under the guidance of clinicians, absolutely prohibit the unauthorized use of drugs; the emergence of pain, you need to promptly go to the hospital for treatment of the original disease.