Simple creatinine is high for six years may be due to long-term excessive exercise and other physiological factors, but it may also be due to hypertensive nephropathy, glomerular disease, etc. If it is caused by pathologic reasons, it can be treated by moderately reducing the exercise, paying attention to rest, and taking medications (such as valsartan, prednisone acetate). 1. Physiological factors If six years of long-term excessive exercise, may lead to muscle metabolism out of creatinine increased, and creatinine is mainly excreted through the kidneys, if the amount of creatinine more than the amount of renal excretion, creatinine may appear on the high side of the situation. If the amount of creatinine exceeds the excretion of kidneys, high creatinine may occur. After a period of time, the creatinine value will be re-checked by moderately reducing the exercise and strengthening the rest. 2. Pathologic factors (1) Hypertension: If the blood pressure control is not satisfactory for a long time, it may damage the kidneys, resulting in the decline of renal function, which can not excrete creatinine normally, thus making the patients have high creatinine. Usually, antihypertensive drugs can be taken to control blood pressure, such as nifedipine tablets, valsartan, etc., to alleviate the damage of hypertension to the kidneys and promote the excretion of creatinine for treatment. (2) Glomerular disease: glomerular disease can also cause elevated creatinine, in this case, we can follow the doctor’s instructions to improve the renal puncture biopsy, to clarify the type of pathology, and give hormone (prednisone acetate), immunosuppressant (tacrolimus), detoxification drugs (nephronic acid) and other treatments. There are many other reasons why creatinine alone is high for six years, so it is recommended that patients go to the hospital in time to have a relevant examination to clarify the cause of the disease and then follow the doctor’s instructions to carry out targeted treatment.