The red spots on the bottom of the foot are considered to be the following diseases: a. Phase II syphilis rash, which occurs after the appearance of cartilage-like ulcers on the vulva, in addition to the red spots on the bottom of the foot, copper-red red spots or macules can also appear on the hands, in clinical treatment can be applied benzathine penicillin intramuscular injection, to play a therapeutic effect of anti-syphilis spirochetes. At the same time to avoid close contact between patients and others to avoid cross-infection. Second, drug dermatitis, can appear copper-red or purplish red spots, in the treatment can choose Epinastine Hydrochloride capsule oral, topical hydrocortisone butyrate ointment mixed with zinc oxide ointment coated.